Highly-tumor-targeted PAD4 inhibitors with PBA modification inhibit tumors in vivo by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils

Zhu, D; Lu, Y; Hu, B; Pang, YH; Liu, BR; Zhang, M; Wang, WJ; Wang, YJ

Wang, YJ (通讯作者)，Capital Med Univ, Coll Pharmaceut Sci, Dept Med Chem, Beijing 100069, Peoples R China.;Wang, WJ (通讯作者)，Capital Med Univ, Beijing Youan Hosp, Beijing Inst Hepatol, Beijing 100069, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 258 ():

Abstract

As a new target for tumor therapy, PAD4 protein, shows excellent antitumor activity, and phenylboronic acid (PBA) could combine with sialic acid on th......

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