Antidepressants inhibit Na(v)1.3, Na(v)1.7, and Na(v)1.8 neuronal voltage-gated sodium channels more potently than Na(v)1.2 and Na(v)1.6 channels expressed in Xenopus oocytes

Horishita, T; Yanagihara, N; Ueno, S; Okura, D; Horishita, R; Minami, T; Ogata, Y; Sudo, Y; Uezono, Y; Sata, T; Kawasaki, T

Horishita, T (reprint author), Univ Occupat & Environm Hlth, Sch Med, Dept Anesthesiol, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2017; 390 (12): 1255

Abstract

Tricyclic antidepressants (TCAs) and duloxetine are used to treat neuropathic pain. However, the mechanisms underlying their analgesic effects remain ......

Full Text Link