Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity

Chandra, A; Lagnado, AB; Farr, JN; Doolittle, M; Tchkonia, T; Kirkland, JL; LeBrasseur, NK; Robbins, PD; Niedernhofer, LJ; Ikeno, Y; Passos, JF; Monroe, DG; Pignolo, RJ; Khosla, S

Pignolo, RJ; Khosla, S (通讯作者)，Mayo Clin, Coll Med, Guggenheim 7,200 First St SW, Rochester, MN 55905 USA.

AGING CELL, 2022; 21 (5):

Abstract

Cellular senescence, which is a major cause of tissue dysfunction with aging and multiple other conditions, is known to be triggered by p16(Ink4a) or ......

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