Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma

Zhao, QT; Huang, L; Qin, GH; Qiao, YM; Ren, FF; Shen, CY; Wang, SM; Liu, SS; Lian, JY; Wang, D; Yu, WN; Zhang, Y

Zhang, Y (corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Biotherapy Ctr, Zhengzhou 450052, Henan, Peoples R China.

CANCER LETTERS, 2021; 518 (): 35

Abstract

Drug resistance remains the major obstacle limiting the effectiveness of chemotherapy for esophageal squamous cell carcinoma (ESCC)[1]. However, how s......

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