Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway

Wang, TJ; Xia, CX; Weng, QT; Wang, KT; Dong, Y; Hao, S; Dong, F; Liu, XF; Liu, LJ; Geng, Y; Guan, YX; Du, J; Cheng, T; Cheng, H; Wang, JY

Wang, JY (通讯作者),Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Expt Hematol, CAS Key Lab Regenerat Biol, Guangzhou, Peoples R China.;Wang, JY (通讯作者),Guangzhou Regenerat Med & Hlth Guangdong Lab, Bioland Lab, Guangzhou, Peoples R China.;Wang, JY (通讯作者),Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou, Peoples R China.;Cheng, H (通讯作者),Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Expt Hematol, Tianjin, Peoples

HAEMATOLOGICA, 2022; 107 (1): 154

Abstract

Hematopoietic stem cells (HSC) are dominantly quiescent under homeostasis, which is a key mechanism of maintaining the HSC pool for life-long hematopo......

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