Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies

Zhang, TT; Ma, JL; Durbin, KR; Montavon, T; Lacy, SE; Jenkins, GJ; Doktor, S; Kalvass, JC

Kalvass, JC (reprint author), AbbVie Inc, DMPK BA, N Chicago, IL 60064 USA.

AAPS JOURNAL, 2019; 21 (5):

Abstract

The pro-inflammatory cytokine interleukin (IL)-23 is a key modulator of the immune response, making it an attractive target for the treatment of autoi......

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