A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics

Rose, JC; Huang, PS; Camp, ND; Ye, J; Leidal, AM; Goreshnik, I; Trevillian, BM; Dickinson, MS; Cunningham-Bryant, D; Debnath, J; Baker, D; Wolf-Yadlin, A; Maly, DJ

Maly, DJ (reprint author), Univ Washington, Dept Chem, Seattle, WA 98195 USA.; Maly, DJ (reprint author), Univ Washington, Dept Biochem, Seattle, WA 98195 USA.

NATURE CHEMICAL BIOLOGY, 2017; 13 (1): 119

Abstract

Synthetic protein switches controlled with user-defined inputs are powerful tools for studying and controlling dynamic cellular processes. To date, th......

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