Amyloidogenic processing of amyloid ? protein precursor (APP) is enhanced in the brains of alcadein ??deficient mice

Gotoh, N; Saito, Y; Hata, S; Saito, H; Ojima, D; Murayama, C; Shigeta, M; Abe, T; Konno, D; Matsuzaki, F; Suzuki, T; Yamamoto, T

Suzuki, T; Yamamoto, T (corresponding author), Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Neurosci, Sapporo, Hokkaido, Japan.; Yamamoto, T (corresponding author), Kagawa Univ, Fac Med, Dept Mol Neurobiol, Takamatsu, Kagawa, Japan.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (28): 9650

Abstract

Alzheimer's disease (AD) is a very common neurodegenerative disorder, chiefly caused by increased production of neurotoxic ?-amyloid (A?) peptide gene......

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