Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

Zhou, JY; Liu, M; Sun, HY; Feng, Y; Xu, LL; Chan, AWH; Tong, JH; Wong, J; Chong, CCN; Lai, PBS; Wang, HKS; Tsang, SW; Goodwin, T; Liu, RH; Huang, L; Chen, ZW; Sung, JJY; Chow, KL; To, KF; Cheng, ASL

Cheng, ASL (reprint author), Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China.; Cheng, ASL (reprint author), Chinese Univ Hong Kong, State Key Lab Digest Dis, Hong Kong, Hong Kong, Peoples R China.

GUT, 2018; 67 (5): 931

Abstract

Objective Myeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. ......

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