Arecoline N-oxide initiates oral carcinogenesis and arecoline N-oxide mercapturic acid attenuates the cancer risk

Nithiyanantham, S; Arumugam, S; Hsu, HT; Chung, CM; Lee, CP; Tsai, MH; Yeh, KT; Luo, SY; Ko, YC

Ko, YC (corresponding author), China Med Univ, China Med Univ Hosp, Environm Omics Dis Res Ctr, 2 Yude Rd, Taichung 40402, Taiwan.

LIFE SCIENCES, 2021; 271 ():

Abstract

Arecoline N-oxide (ANO), an oxidative metabolite of the areca nut, is a predictable initiator in carcinogenesis. The mechanisms of arecoline metabolit......

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