Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia

Barghout, SH; Patel, PS; Wang, XM; Xu, GW; Kavanagh, S; Halgas, O; Zarabi, SF; Gronda, M; Hurren, R; Jeyaraju, DV; MacLean, N; Brennan, S; Hyer, ML; Berger, A; Traore, T; Milhollen, M; Smith, AC; Minden, MD; Pai, EF; Hakem, R; Schimmer, AD

Schimmer, AD (reprint author), Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.; Schimmer, AD (reprint author), Univ Toronto, Fac Med, Dept Med Biophys, Toronto, ON, Canada.

LEUKEMIA, 2019; 33 (1): 37

Abstract

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic......

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