APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

Ryu, JH; Ge, MY; Merscher, S; Rosenberg, AZ; Desante, M; Roshanravan, H; Okamoto, K; Shin, MK; Hoek, M; Fornoni, A; Kopp, JB

Kopp, JB (reprint author), NIDDK, Kidney Dis Sect, NIH, Bethesda, MD 20892 USA.; Fornoni, A (reprint author), Univ Miami, Sch Med, Div Nephrol & Hypertens, Miami, FL 33136 USA.; Fornoni, A (reprint author), Univ Miami, Sch Med, Peggy & Harold Katz Drug Di

PLOS ONE, 2019; 14 (4):

Abstract

Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in Afri......

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