Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Liang, KW; Volk, AG; Haug, JS; Marshall, SA; Woodfin, AR; Bartom, ET; Gilmore, JM; Florens, L; Washburn, MP; Sullivan, KD; Espinosa, JM; Cannova, J; Zhang, JW; Smith, ER; Crispino, JD; Shilatifard, A

Shilatifard, A (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Biochem & Mol Genet, 320 E Super St, Chicago, IL 60611 USA.; Shilatifard, A (reprint author), Stowers Inst Med Res, 1000 E 50th St, Kansas City, MO 64110 USA.; Shilatifard, A (repr

CELL, 2017; 168 (1-2): 59

Abstract

Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Des......

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