Discovery of spirooxindole-ferrocene hybrids as novel MDM2 inhibitors

Mu, J; Xie, X; Xiong, SS; Zhang, YH; Wang, YT; Zhao, Q; Zhu, HP; Huang, W; He, G

He, G (corresponding author), Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.; He, G (corresponding author), Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China.; Huang, W (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Hosp Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.

CHINESE CHEMICAL LETTERS, 2021; 32 (6): 1897

Abstract

A series of spirooxindole-ferrocene hybrids bearing five or four contiguous chiral centers were designed and synthesized via organocatalysis. In vitro......

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