Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

Gocho, Y; Liu, JJ; Hu, JZ; Yang, WT; Dharia, NV; Zhang, JL; Shi, H; Du, GQ; John, A; Lin, TN; Hunt, J; Huang, X; Ju, BS; Rowland, L; Shi, L; Maxwell, D; Smart, B; Crews, KR; Yang, WJ; Hagiwara, K; Zhang, YC; Roberts, K; Wang, H; Jabbour, E; Stock, W; Eisfelder, B; Paietta, E; Newman, S; Roti, G; Litzow, M; Easton, J; Zhang, JH; Peng, JM; Chi, HB; Pounds, S; Relling, MV; Inaba, H; Zhu, XF; Kornblau, S; Pui, CH; Konopleva, M; Teachey, D; Mullighan, CG; Stegmaier, K; Evans, WE; Yu, JY; Yang, JJ

Yang, JJ (corresponding author), St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA.; Yu, JY (corresponding author), St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA.; Yang, JJ (corresponding author), St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA.

NATURE CANCER, 2021; 2 (3): 284

Abstract

Yang and colleagues perform a network system-pharmacology approach and clinical data integration, and identify LCK and BCL2 signaling as the molecular......

Full Text Link