The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation

Yang, J; Wei, P; Barbi, J; Huang, QR; Yang, E; Bai, YK; Nie, J; Gao, YH; Tao, JH; Lu, Y; Xie, CC; Hou, XX; Ren, JZ; Wu, XM; Meng, J; Zhang, Y; Fu, J; Kou, W; Gao, YY; Chen, ZJ; Liang, R; Tsun, A; Li, D; Guo, WZ; Zhang, SJ; Zheng, SG; Niu, JQ; Galardy, P; Tong, XM; Shi, GC; Li, HB; Pan, F; Li, B

Li, B (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai, Peoples R China.; Li, B (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Dept Immunol & Microbiol, Shanghai, Peoples R China.; Li, B (corresponding author), Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders Chongqin, China Int Sci & Technol Cooperat Base Child Dev &, Childrens Hosp,Dept Otolaryngol,Minist Educ,Key L, Chongqing, Peoples R China.; Pan, F (corresponding author), Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Immunol & Hematopoiesis Div,Dept Oncol, Baltimore, MD 21218 USA.; Li, B (corresponding author), Zhengzhou Univ, Henan Key Lab Digest Organ Transplantat, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.; Li, B (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Inst Resp Dis, Dept Pulm & Crit Care Med,Ruijin Hosp, Shanghai, Peoples R China.; Li, HB (corresponding author), Fudan Univ, Affiliated Eye & ENT Hosp, ENT Dept, Shanghai, Peoples R China.; Pan, F (corresponding author), Chinese Acad Sci, Inst Adv Technol, Shenzhen, Peoples R China.

EMBO REPORTS, 2020; 21 (9):

Abstract

The transcription factor forkhead box P3 (FOXP3) is essential for the development of regulatory T cells (Tregs) and their function in immune homeostas......

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