Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity

Yang, SJ; Jeon, SJ; Nguyen, TV; Deshaies, RJ; Park, CS; Lee, KM

Park, CS (corresponding author), Gwangju Inst Sci & Technol GIST, Gwangju 61005, South Korea.; Lee, KM (corresponding author), Pusan Natl Univ, Miryang 50463, South Korea.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2020; 1867 (8):

Abstract

Cereblon (CRBN), a substrate receptor for Cullin-ring E3 ubiquitin ligase (CRL), is a major target protein of immunomodulatory drugs. An earlier study......

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