Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s

Daugan, MV; Revel, M; Russick, J; Dragon-Durey, MA; Gaboriaud, C; Robe-Rybkine, T; Poillerat, V; Grunenwald, A; Lacroix, G; Bougouin, A; Meylan, M; Verkarre, V; Oudard, SM; Mejean, A; Vano, YA; Perkins, G; Validire, P; Cathelineau, X; Sanchez-Salas, R; Damotte, D; Fremeaux-Bacchi, V; Cremer, I; Sautes-Fridman, C; Fridman, WH; Roumenina, LT

Roumenina, LT (corresponding author), INSERM, UMRS 1138, Cordeliers Res Ctr, Inflammat Complement & Canc, 15 Rue Ecole Med,Entrance E,3rd Floor, F-75006 Paris, France.

CANCER IMMUNOLOGY RESEARCH, 2021; 9 (8): 891

Abstract

The complement system plays a complex role in cancer. In clear cell renal cell carcinoma (ccRCC), local production of complement proteins drives tumor......

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