Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6

Lee, YE; Go, GY; Koh, EY; Yoon, HN; Seo, M; Hong, SM; Jeong, JH; Kim, JC; Cho, D; Kim, TS; Kim, SC; Jun, E; Jang, M

Jang, M (通讯作者)，Korea Inst Sci & Technol, Med Mat Res Ctr, Biomed Res Div, Seoul, South Korea.;Jun, E (通讯作者)，Univ Ulsan, Asan Inst Life Sci, Coll Med, Dept Convergence Med, Seoul, South Korea.;Jun, E (通讯作者)，Asan Med Ctr, Seoul, South Korea.;Kim, SC; Jun, E (通讯作者)，Univ Ulsan, Coll Med, Asan Med Ctr, Div Hepatobiliary & Pancreat Surg,Dept Surg, Seoul, South Korea.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2023; 11 (2):

Abstract

BackgroundCancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) contribute to an impaired functionality of natural killer (NK) cell......

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