Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

Santamaria, S; Fedorov, O; McCafferty, J; Murphy, G; Dudhia, J; Nagase, H; Yamamoto, K

Yamamoto, K (reprint author), Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Roosevelt Dr, Oxford OX3 7FY, England.

MABS, 2017; 9 (4): 595

Abstract

The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface end......

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