Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition

Rymarchyk, S; Kang, WJ; Cen, Y

Cen, Y (corresponding author), Virginia Commonwealth Univ, Dept Med Chem, Richmond, VA 23219 USA.; Cen, Y (corresponding author), Virginia Commonwealth Univ, Inst Struct Biol Drug Discovery & Dev, Richmond, VA 23219 USA.

BIOMOLECULES, 2021; 11 (2):

Abstract

SIRT1 is the most extensively studied human sirtuin with a broad spectrum of endogenous targets. It has been implicated in the regulation of a myriad ......

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