Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis

Wang, YP; Jia, LL; Shen, J; Wang, YD; Fu, ZR; Su, SA; Cai, ZJ; Wang, JA; Xiang, MX

Cai, ZJ; Xiang, MX (reprint author), Zhejiang Univ, Affiliated Hosp 2, Dept Cardiol, Cardiovasc Key Lab Zhejiang Prov,Sch Med, Hangzhou, Zhejiang, Peoples R China.

PLOS PATHOGENS, 2018; 14 (1):

Abstract

Cathepsin B (CatB) is a cysteine proteolytic enzyme widely expressed in various cells and mainly located in the lysosomes. It contributes to the patho......

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