Multiplex genome editing of mammalian cells for producing recombinant heparin

Thacker, BE; Thorne, KJ; Cartwright, C; Park, J; Glass, K; Chea, A; Kellman, BP; Lewis, NE; Wang, ZP; Di Nardo, A; Sharfstein, ST; Jeske, W; Walenga, J; Hogwood, J; Gray, E; Mulloy, B; Esko, JD; Glass, CA

Glass, CA (通讯作者),3550 Gen Atom Ct,G02-102, San Diego, CA 92121 USA.

METABOLIC ENGINEERING, 2022; 70 (): 155

Abstract

Heparin is an essential anticoagulant used for treating and preventing thrombosis. However, the complexity of heparin has hindered the development of ......

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