HIF-1-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia-MedSci.cn

HIF-1-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia

Karagiota, A; Kourti, M; Simos, G; Mylonis, I

Simos, G; Mylonis, I (reprint author), Univ Thessaly, Biochem Lab, Fac Med, Biopolis 41500, Larissa, Greece.; Simos, G (reprint author), McGill Univ, Fac Med, Gerald Bronfman Dept Oncol, Montreal, PQ, Canada.

Abstract

Hypoxia is frequently encountered in the microenvironment of solid tumors. Hypoxia-inducible factors (HIFs), the main effectors of cell response to hy......

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HIF-1-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia

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