THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy

Li, CS; Chi, H; Deng, SY; Wang, HB; Yao, H; Wang, YG; Chen, DW; Guo, X; Fang, JY; He, F; Xu, J

Xu, J (corresponding author), Fudan Univ, Zhongshan Xuhui Hosp, Shanghai Xuhui Cent Hosp, Inst Biomed Sci,Shanghai Key Lab Med Epigenet,Min, Shanghai, Peoples R China.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (8):

Abstract

Background The abnormal upregulation of programmed death-ligand 1 (PD-L1) in cancer cells inhibits T cell-mediated cytotoxicity, but the molecular mec......

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