Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

Iyer, S; Uren, RT; Dengler, MA; Shi, MX; Uno, E; Adams, JM; Dewson, G; Kluck, RM

Kluck, RM (corresponding author), Walter & Eliza Hall Inst Med Res, 1G Royal Parade, Parkville, Vic 3052, Australia.; Kluck, RM (corresponding author), Univ Melbourne, Dept Med Biol, Melbourne, Vic 3052, Australia.

CELL DEATH & DISEASE, 2020; 11 (4):

Abstract

BAK and BAX, which drive commitment to apoptosis, are activated principally by certain BH3-only proteins that bind them and trigger major rearrangemen......

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