Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization

Mitropoulou, AN; Ceska, T; Heads, JT; Beavil, AJ; Henry, AJ; McDonnell, JM; Sutton, BJ; Davies, AM

McDonnell, JM; Sutton, BJ; Davies, AM (corresponding author), Kings Coll London, Randall Ctr Cell & Mol Biophys, New Hunts House, London SE1 1UL, England.; McDonnell, JM; Sutton, BJ; Davies, AM (corresponding author), MRC, London, England.; McDonnell, JM; Sutton, BJ; Davies, AM (corresponding author), Asthma UK Ctr Allerg Mech Asthma, London, England.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2020; 76 (): 116

Abstract

Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc epsilon RI-bound IgE triggers mast cell......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索