Shared structural mechanisms of general anaesthetics and benzodiazepines

Kim, JJ; Gharpure, A; Teng, JF; Zhuang, YX; Howard, RJ; Zhu, ST; Noviello, CM; Walsh, RM; Lindahl, E; Hibbs, RE

Hibbs, RE (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA.

NATURE, 2020; 585 (7824): 303

Abstract

Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of gamma-aminobutyric acid type A (GABA(A)) receptors to ......

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