Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Wang, YX; Gao, J; Zhao, S; Song, Y; Huang, H; Zhu, GW; Jiao, PL; Xu, XQ; Zhang, GS; Wang, KW; Zhang, LR; Liu, ZM

Zhang, LR; Liu, ZM (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.; Wang, KW (corresponding author), Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Peoples R China.

ACTA PHARMACEUTICA SINICA B, 2021; 11 (7): 1947

Abstract

Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic act......

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