Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes

La Sala, G; Olieric, N; Sharma, A; Viti, F; Perez, FDB; Huang, L; Tonra, JR; Lloyd, GK; Decherchi, S; Diaz, JF; Steinmetz, MO; Cavalli, A

Cavalli, A (reprint author), Ist Italiano Tecnol, Computat & Chem Biol, Via Morego 30, I-16163 Genoa, Italy.; Steinmetz, MO (reprint author), Paul Scherrer Inst, Dept Biol & Chem, Lab Biomol Res, CH-5232 Villigen, Switzerland.; Steinmetz, MO (reprint auth

CHEM, 2019; 5 (11): 2969

Abstract

alpha beta-Tubulin is a validated target for anticancer drug discovery, and molecules binding to this protein are used to treat several types of tumor......

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