Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck

Dorman, HR; Close, D; Wingert, BM; Camacho, CJ; Johnston, PA; Smithgall, TE

Smithgall, TE (reprint author), Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA 15213 USA.

FRONTIERS IN CHEMISTRY, 2019; 7 ():

Abstract

The eight mammalian Src-family tyrosine kinases are dynamic, multi-domain structures, which adopt distinct "open" and "closed" conformations. In the c......

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