Mechanistic insight into substrate processing and allosteric inhibition of human p97

Pan, M; Yu, YY; Ai, HS; Zheng, QY; Xie, Y; Liu, L; Zhao, ML

Pan, M; Zhao, ML (corresponding author), Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA.; Liu, L (corresponding author), Tsinghua Univ, Dept Chem, Tsinghua Peking Ctr Life Sci, Beijing, Peoples R China.

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021; 28 (7): 614

Abstract

A series of high-resolution cryo-EM structures of substrate-engaged human p97 AAA ATPase reveal critical conformational changes of the intersubunit si......

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