Heterodimerization With 5-HT2BR Is Indispensable for beta(2)AR-Mediated Cardioprotection

Song, Y; Xu, CJ; Liu, JF; Li, YL; Wang, H; Shan, D; Wainer, IW; Hu, XL; Zhang, Y; Woo, AYH; Xiao, RP

Zhang, Y (corresponding author), Peking Univ, Inst Mol Med, Room 236,New Life Sci Bldg,5 Yiheyuan Rd, Beijing 100871, Peoples R China.; Woo, AYH (corresponding author), Shenyang Pharmaceut Univ, Dept Pharmacol, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.

CIRCULATION RESEARCH, 2021; 128 (2): 262

Abstract

Rationale: The beta(2)-adrenoceptor (beta(2)-AR), a prototypical GPCR (G protein-coupled receptor), couples to both G(s) and G(i) proteins. Stimulatio......

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