Development of 18F-Labeled PET Tracer Candidates for Imaging of the Abelson Non-receptor Tyrosine Kinase in Parkinson's Disease

Stéen, EJL; Park, AY; Beaino, W; Gadhe, CG; Kooijman, E; Schuit, RC; Schreurs, M; Leferink, P; Hoozemans, JJM; Kim, JE; Lee, J; Windhorst, AD

Stéen, EJL; Windhorst, AD (通讯作者)，Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC locat, NL-1081 HV Amsterdam, Netherlands.;Lee, J (通讯作者)，1ST Biotherapeut Inc, Seongnam Si 13493, Gyeonggi Do, South Korea.

JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (18): 12990

Abstract

Activated Abelson non-receptor tyrosine kinase (c-Abl) plays a harmful role in neurodegenerative conditions such as Parkinson's disease (PD). Inhibiti......

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