IL-2 regulates tumor-reactive CD8(+) T cell exhaustion by activating the aryl hydrocarbon receptor

Liu, YY; Zhou, NN; Zhou, L; Wang, J; Zhou, YB; Zhang, TZ; Fang, Y; Deng, JW; Gao, YF; Liang, XY; Lv, JD; Wang, ZF; Xie, J; Xue, YB; Zhang, HF; Ma, JW; Tang, K; Fang, YL; Cheng, FR; Zhang, CJ; Dong, B; Zhao, YZ; Yuan, P; Gao, QL; Zhang, HZ; Qin, FXF; Huang, B

Huang, B (corresponding author), Chinese Acad Med Sci CAMS & Peking Union Med Coll, Inst Basic Med Sci, Dept Immunol, Beijing, Peoples R China.; Huang, B (corresponding author), Chinese Acad Med Sci CAMS & Peking Union Med Coll, Inst Basic Med Sci, Natl Key Lab Med Mol Biol, Beijing, Peoples R China.; Huang, B (corresponding author), CAMS, Clin Immunol Ctr, Beijing, Peoples R China.; Huang, B (corresponding author), Huazhong Univ Sci & Technol, Dept Biochem & Mol Biol, Tongji Med Coll, Wuhan, Pe

NATURE IMMUNOLOGY, 2021; 22 (3): 358

Abstract

CD8(+) T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the ......

Full Text Link