Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing

Kober, DL; Radhakrishnan, A; Goldstein, JL; Brown, MS; Clark, LD; Bai, XC; Rosenbaum, DM

Bai, XC; Rosenbaum, DM (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Biophys, Dallas, TX 75390 USA.; Radhakrishnan, A (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA.

CELL, 2021; 184 (14): 3689

Abstract

The cholesterol-sensing protein Scap induces cholesterol synthesis by transporting membrane-bound transcription factors called sterol regulatory eleme......

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