The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

Joshi, SK; Nechiporuk, T; Bottomly, D; Piehowski, PD; Reisz, JA; Pittsenbarger, J; Kaempf, A; Gosline, SJC; Wang, YT; Hansen, JR; Gritsenko, MA; Hutchinson, C; Weitz, KK; Moon, J; Cendali, F; Fillmore, TL; Tsai, CF; Schepmoes, AA; Shi, TJ; Arshad, OA; McDermott, JE; Babur, O; Watanabe-Smith, K; Demir, E; D'Alessandro, A; Liu, T; Tognon, CE; Tyner, JW; McWeeney, SK; Rodland, KD; Druker, BJ; Traer, E

Traer, E (corresponding author), Oregon Hlth & Sci Univ, Knight Canc Inst, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.; Traer, E (corresponding author), Oregon Hlth & Sci Univ, Dept Med, Div Hematol & Med Oncol, Portland, OR 97201 USA.; Traer, E (corresponding author), Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97201 USA.

CANCER CELL, 2021; 39 (7): 999

Abstract

Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute myeloid leukemia (AML). Early resistance is mediated by the ......

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