Reducing hyperactivated BAP1 attenuates mutant ASXL1-driven myeloid malignancies in human haematopoietic cells

Bai, JJ; Chen, ZZ; Chen, C; Zhang, MY; Zhang, YH; Song, JZ; Yuan, JJ; Jiang, X; Xing, W; Yang, J; Bai, J; Zhou, Y

Zhou, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Blood Dis, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China.; Zhou, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin 300020, Peoples R China.; Bai, J (corresponding author), Tianjin Med Univ, Affiliated Hosp 2, Dept Hematol, Tianjin 300211, Peoples R China.

CANCER LETTERS, 2021; 519 (): 78

Abstract

Additional sex combs-like 1 (ASXL1) is frequently mutated in a variety of myeloid malignancies, resulting in expression of a C-terminal-truncated ASXL......

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