Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity

Edwards, ESJ; Bier, J; Cole, TS; Wong, M; Hsu, P; Berglund, LJ; Boztug, K; Lau, A; Gostick, E; Price, DA; O'Sullivan, M; Meyts, I; Choo, S; Gray, P; Holland, SM; Deenick, EK; Uzel, G; Tangye, SG

Tangye, SG (reprint author), Garvan Inst Med Res, Div Immunol, 384 Victoria St, Darlinghurst, NSW 2010, Australia.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019; 143 (1): 276

Abstract

Background: Germline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic p110 delta subunit of phosphoinositide 3-kinase (PI3K), result......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索