FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1-TYMS axis uncoupling in 5-FU resistance

Intuyod, K; Saavedra-Garcia, P; Zona, S; Lai, CF; Jiramongkol, Y; Vaeteewoottacharn, K; Pairojkul, C; Yao, S; Yong, JS; Trakansuebkul, S; Waraasawapati, S; Luvira, V; Wongkham, S; Pinlaor, S; Lam, EWF

Lam, EWF (reprint author), Imperial Coll London, Dept Surg & Canc, Hammersmith Hosp Campus, London W12 0NN, England.; Pinlaor, S (reprint author), Khon Kaen Univ, Cholangiocarcinoma Res Inst, Khon Kaen 40002, Thailand.; Pinlaor, S (reprint author), Khon K

CELL DEATH & DISEASE, 2018; 9 ():

Abstract

Fluorouracil (5-FU) is the first-line chemotherapeutic drug for cholangiocarcinoma (CCA), but its efficacy has been compromised by the development of ......

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