Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload

Liu, YR; Bell, BA; Song, Y; Zhang, K; Anderson, B; Axelsen, PH; Bohannan, W; Agbaga, MP; Park, HG; James, G; Brenna, JT; Schmidt, K; Dunaief, JL; Shchepinov, MS

Dunaief, JL (通讯作者)，Univ Penn, FM Kirby Ctr Mol Ophthalmol, Scheie Eye Inst, Perelman Sch Med, 305 Stellar Chance Lab,422 Curie Blvd, Philadelphia, PA 19104 USA.;Shchepinov, MS (通讯作者)，Retrotope Inc, 4300 El Camino Real, Los Altos, CA 94022 USA.

AGING CELL, 2022; 21 (4):

Abstract

Oxidative stress plays a central role in age-related macular degeneration (AMD). Iron, a potent generator of hydroxyl radicals through the Fenton reac......

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