Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant

Hamasy, A; Wang, Q; Blomberg, KEM; Mohammad, DK; Yu, L; Vihinen, M; Berglof, A; Smith, CIE

Hamasy, A (reprint author), Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, MCG,KFC,Clin Res Ctr, SE-14186 Huddinge, Sweden.

LEUKEMIA, 2017; 31 (1): 177

Abstract

Irreversible Bruton tyrosine kinase (BTK) inhibitors, ibrutinib and acalabrutinib have demonstrated remarkable clinical responses in multiple B-cell m......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索