Integration of innate immune signalling by caspase-8 cleavage of N4BP1

Gitlin, AD; Heger, K; Schubert, AF; Reja, R; Yan, DH; Pham, VC; Suto, E; Zhang, J; Kwon, YSC; Freund, EC; Kang, J; Pham, A; Caothien, R; Bacarro, N; Hinkle, T; Xu, M; McKenzie, BS; Haley, B; Lee, WP; Lill, JR; Roose-Girma, M; Dohse, M; Webster, JD; Newton, K; Dixit, VM

Gitlin, AD (corresponding author), Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA.; Gitlin, AD; Newton, K; Dixit, VM (corresponding author), Genentech Inc, Dept Physiol Chem, San Francisco, CA 94080 USA.

NATURE, 2020; 587 (7833): 275

Abstract

Mutations in the death receptor FAS(1,2) or its ligand FASL(3) cause autoimmune lymphoproliferative syndrome, whereas mutations in caspase-8 or its ad......

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