The N-6-methyladenosine (m(6)A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA

Liu, YH; Liu, ZJ; Tang, H; Shen, YC; Gong, Z; Xie, N; Zhang, X; Wang, WG; Kong, W; Zhou, Y; Fu, Y

Fu, Y (reprint author), Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China.; Zhou, Y (reprint author), Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing, Peoples R China.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2019; 317 (4): C762

Abstract

Compelling evidence indicates that epigenetic regulations orchestrate dynamic macrophage polarization. N-6-methyladenosine (m(6)A) methylation is the ......

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