Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery

Kamiya, T; Hira, D; Nakajima, R; Shinoda, K; Motomochi, A; Morikochi, A; Ikeda, Y; Isono, T; Akabane, M; Ueshima, S; Kakumoto, M; Imai, S; Morita, SY; Terada, T

Terada, T (通讯作者)，Shiga Univ Med Sci Hosp, Dept Pharm, Otsu, Shiga 5202192, Japan.;Terada, T (通讯作者)，Kyoto Univ Hosp, Dept Clin Pharmacol & Therapeut, Sakyo Ku, Kyoto 6068507, Japan.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2023; 46 (7): 907

Abstract

Tramadol is metabolized by CYP2D6 to an active metabolite, which in turn acts as an analgesic. This study aimed to investigate the impact of CYP2D6 ge......

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