Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51)

Geiger, TM; Walz, M; Meyners, C; Kuehn, A; Dreizler, JK; Sugiarto, WO; Maciel, EVS; Zheng, M; Lermyte, F; Hausch, F

Hausch, F (通讯作者)，Tech Univ Darmstadt, Clemens Schopf Inst, Dept Chem & Biochem, Peter Grunberg Str 4, D-64287 Darmstadt, Germany.;Hausch, F (通讯作者)，Tech Univ Darmstadt, Ctr Synthet Biol, D-64283 Darmstadt, Germany.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023; ():

Abstract

The FK506-binding protein 51 (FKBP51) is a promising target in a variety of disorders including depression, chronic pain, and obesity. Previous FKBP51......

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