Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice

Chen, XQ; Yu, YH; Zheng, P; Jin, TT; He, M; Zheng, MX; Song, XQ; Jones, A; Huang, XF

Huang, XF (corresponding author), Univ Wollongong, Sch Med, Illawarra Hlth & Med Res Inst & Mol Horizons, Wollongong, NSW 2522, Australia.; Yu, YH (corresponding author), Xuzhou Med Univ, Dept Pathogen Biol & Immunol, Xuzhou 221004, Jiangsu, Peoples R China.; Yu, YH (corresponding author), Jiangsu Key Lab Immun & Metab, Xuzhou 221004, Jiangsu, Peoples R China.

PSYCHONEUROENDOCRINOLOGY, 2020; 114 ():

Abstract

Second generation antipsychotics, particularly olanzapine, induce severe obesity, which is associated with their antagonistic effect on the histamine ......

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