Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells

Kim, SH; Son, KM; Kim, KY; Yu, SN; Park, SG; Kim, YW; Nam, HW; Suh, JT; Ji, JH; Ahn, SC

Ahn, SC (reprint author), Pusan Natl Univ, Sch Med, Dept Microbiol & Immunol, Yangsan, South Korea.; Ji, JH (reprint author), Ajou Univ, Sch Med, Genom Instabil Res Ctr, Suwon, South Korea.; Ahn, SC (reprint author), Pusan Natl Univ, Immunoregulatory Ther

PHARMACOLOGICAL REPORTS, 2017; 69 (5): 878

Abstract

Background: A natural compound deoxypodophyllotoxin (DPT) possesses potent anti-proliferative and anti-tumor properties on several cancer types. It tr......

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