MiR-200a Regulates CDK4/6 Inhibitor Effect by Targeting CDK6 in Metastatic Melanoma

Bustos, MA; Ono, S; Marzese, DM; Oyama, T; Iida, Y; Cheung, G; Nelson, N; Hsu, SC; Yu, Q; Hoon, DSB

Hoon, DSB (reprint author), Providence St Johns Hlth Ctr, Dept Translat Mol Med, Div Mol Oncol, John Wayne Canc Inst, 2200 Santa Monica Blvd, Santa Monica, CA 90404 USA.

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017; 137 (9): 1955

Abstract

The CDK4/6 pathway is frequently dysregulated in cutaneous melanoma. Recently, CDK4/6 inhibitors have shown promising clinical activity against severa......

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