Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

Chen, L; Jiao, TY; Liu, WW; Luo, YH; Wang, J; Guo, XZ; Tong, X; Lin, ZM; Sun, CY; Wang, KL; He, YF; Zhang, YW; Xu, HL; Wang, JW; Zuo, JP; Ding, QR; He, SJ; Gonzalez, FJ; Xie, C

He, SJ; Xie, C (通讯作者)，Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China.;He, SJ; Xie, C (通讯作者)，Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;Gonzalez, FJ (通讯作者)，NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.

CELL STEM CELL, 2022; 29 (9): 1366

Abstract

Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease (IBD), the role of hepatic BA metabolism in the pathogenesis......

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